Human Leukocyte antigen B27 (HLA- B27) belongs to a group of cell surface glycoproteins which are expressed on most nucleated human cells and platelets. It is a major histocompatibility complex (MHC) class I molecule. The presence of HLA – B27 is strongly associated with ankylosing spondylitis and some inflammatory disorders like Reiter’s syndrome, inflammatory bowel syndrome, etc. The binding ability of specific monoclonal antibodies to the antigenic determinants expressed by leucocytes on the surface forms the basis of this test. HLA-B 27 test is generally advised in patients suffering from joint pain where the diagnosis of ankylosing spondylitis is suspected. A positive test result indicates higher chances of developing this disease. Avail of the service by booking the HLA-B27 test online at an affordable rate, at your doorstep.
HLA-B27 is a protein found on white blood cells that helps the immune system identify harmful substances. It’s also the name of a blood test that checks for the presence of this protein.
What is HLA-B27 associated with?
Ankylosing spondylitis: An autoimmune disease that affects the spine. Most people with ankylosing spondylitis have the HLA-B27 gene, but many people with the gene never develop the disease.
Reactive arthritis: An autoimmune disease that affects the joints. 60–85% of patients with reactive arthritis are HLA-B27 positive.
Juvenile arthritis: An autoimmune disease that occurs in children.
How is the test performed?
The HLA-B27 test is a blood draw that’s usually taken from the arm.
A healthcare provider in a doctor’s office or a clinical lab administers the test.
The blood is collected in a tube and sent to a lab for analysis.
HLA-B27 prevalence
The prevalence of HLA-B27 varies between populations.
In the UK, HLA-B27 is present in 90–95% of patients with ankylosing spondylitis.
In the general population, 8 in every 100 people have the HLA-B27 gene variant.
₹2,090.00Original price was: ₹2,090.00.₹1,500.00Current price is: ₹1,500.00.
